Ferricrocin, a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus.

Abstract

Iron is an essential metal for virtually all organisms. Iron acquisition is well characterized for various organisms, whereas intracellular iron distribution is poorly understood. In contrast to bacteria, plants, and animals, most fungi lack ferritin-mediated iron storage but possess an intracellular siderophore shown to be involved in iron storage. Here we demonstrate that deficiency in the intracellular siderophore ferricrocin causes iron starvation in conidia of Aspergillus fumigatus, demonstrating that ferricrocin is also involved in intra- and transcellular iron distribution. Thus, ferricrocin represents the first intracellular iron transporter identified in any organism.

• Authors: Anja Wallner, Michael Blatzer, Markus Schrettl, Bettina Sarg, Herbert Lindner, Hubertus Haas
• Journal: Applied and environmental microbiology (Appl Environ Microbiol) Vol. 75 Issue 12 Pg. 4194-6 (Jun 2009) ISSN: 1098-5336 [Electronic] United States
• PMID: 19376908 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Siderophores
• Ferrichrome
• ferricrocin
• Iron

Topics

• Aspergillus fumigatus (metabolism)
• Ferrichrome (analogs & derivatives, metabolism)
• Iron (metabolism)
• Siderophores (metabolism)
• Spores, Fungal (metabolism)