Abstract | PURPOSE OF REVIEW:
Mitochondrial dysfunction is a major etiopathogenic event suspected to cause lipodystrophy in HIV-1-infected patients undergoing antiretroviral treatment. As adipose tissue is the main tissue affected, the present review provides an up-to-date evaluation of the evidence for mitochondrial alterations elicited by antiretroviral therapy, specifically in adipose tissue, and the potential of these abnormalities to elicit the multiple features of the lipodystrophy syndrome. RECENT FINDINGS: SUMMARY: Complex mitochondrial disturbances in adipose tissue elicited by antiretroviral therapy may lead to lipoatrophy and have overall consequences in systemic metabolism via alterations in adipokine release.
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Authors | Francesc Villarroya, Pere Domingo, Marta Giralt |
Journal | Current opinion in HIV and AIDS
(Curr Opin HIV AIDS)
Vol. 2
Issue 4
Pg. 261-7
(Jul 2007)
ISSN: 1746-6318 [Electronic] United States |
PMID | 19372897
(Publication Type: Journal Article)
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