Abstract | OBJECTIVE: METHODS: RESULTS: The 21 patients had a mean age of 61 years, a mean disease duration of 11.3 years, and a mean remission duration at TNFalpha antagonist discontinuation of 19.2 months. The TNFalpha antagonist was infliximab in 2 patients, adalimumab in 5, and etanercept in 14; and 14 patients were taking a concomitant DMARD. The number of patients still in remission after TNFalpha antagonist discontinuation was 9/20 after 6 months and 5/20 after 12 months. Mean time to relapse was 14.7 weeks. While off TNFalpha antagonist therapy, 3 of the 5 relapse-free patients after 12 months were on DMARD therapy, compared to 11 of the 15 patients who relapsed. Compared to the 15 patients who relapsed, the 5 relapse-free patients had a longer time on TNFalpha antagonist therapy (56 months vs. 35 months, P=0.012) and a longer time in remission on TNFalpha antagonist therapy (35 months vs.14.5 months, P=0.04). The 15 patients who relapsed consistently achieved a remission after resuming TNFalpha antagonist therapy; the remission occurred within 2 months in 13 patients. CONCLUSION:
TNFalpha antagonist discontinuation in patients in remission of RA was followed by a relapse within 12 months in 75% of cases. Relapsing patients responded well to resumption of the same TNFalpha antagonist.
|
Authors | Olivier Brocq, Elodie Millasseau, Christine Albert, Christian Grisot, Philippe Flory, Christian-Hubert Roux, Liana Euller-Ziegler |
Journal | Joint bone spine
(Joint Bone Spine)
Vol. 76
Issue 4
Pg. 350-5
(Jul 2009)
ISSN: 1778-7254 [Electronic] France |
PMID | 19362504
(Publication Type: Journal Article)
|
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antirheumatic Agents
- Immunoglobulin G
- Receptors, Tumor Necrosis Factor
- Tumor Necrosis Factor-alpha
- Infliximab
- Adalimumab
- Etanercept
|
Topics |
- Adalimumab
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
- Antirheumatic Agents
(therapeutic use)
- Arthritis, Rheumatoid
(drug therapy)
- Etanercept
- Female
- Humans
- Immunoglobulin G
(therapeutic use)
- Infliximab
- Male
- Middle Aged
- Receptors, Tumor Necrosis Factor
(therapeutic use)
- Recurrence
- Remission Induction
- Retrospective Studies
- Time Factors
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Withholding Treatment
|