[New insights of ARB in central nervous system].

Abstract

Renin angiotensin aldosterone system (RAAS) in the central nervous system (CNS) and therapeutical effects of angiotensin II receptor blockers (ARBs) have been highlighted. In stroke, clinical trials exhibit to prevent primary onset or recurrence of stroke beyond anti-hypertensive effect, inhibition of atrial fibrillation and diabetes mellitus. ARB could be also expected to prevent cognitive impairment induced by such as Alzheimer disease, stroke and metabolic syndrome; however, clinical evidence has not been revealed to date. Angiotensin II levels in cerebrospinal fluid in patients with neurodegenerative diseases such as multiple sclerosis and amyotrophic lateral sclerosis is reduced, suggesting the role of RAAS in neural intractable diseases. These findings will provide us new therapeutic approaches of ARB in CNS disorder in t hefuture.

• Authors: Masaki Mogi, Masatsugu Horiuchi
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 67 Issue 4 Pg. 735-41 (Apr 2009) ISSN: 0047-1852 [Print] Japan
• PMID: 19348236 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Angiotensin Receptor Antagonists

Topics

• Alzheimer Disease (drug therapy)
• Angiotensin Receptor Antagonists
• Animals
• Brain Diseases (drug therapy)
• Central Nervous System (physiology)
• Humans
• Stroke (drug therapy)