The effect of photodynamic therapy on tumor angiogenesis.

Abstract

Photodynamic therapy (PDT), the activation of a photosensitive drug in tumor tissue with light of specific wavelength, has been used effectively to treat certain solid tumors. Though therapeutic responses are encouraging, PDT-mediated oxidative stress can act as an angiogenic switch that ultimately leads to neovascularization and tumor recurrence. This article explores the effect of PDT on angiogenesis in different tumor models. Overexpression of proangiogenic vascular endothelial growth factor, cyclooxygenase-2 and matrix metalloproteases has often been reported post-illumination. Recent clinical studies have demonstrated that inhibiting angiogenesis after chemotherapy and radiotherapy is an attractive and valuable approach to cancer treatment. In this review, we report the effective therapeutic strategy of combining angiogenesis inhibitors with PDT to control and treat tumors.

• Authors: Ramaswamy Bhuvaneswari, Yik Yuen Gan, Khee Chee Soo, Malini Olivo
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 66 Issue 14 Pg. 2275-83 (Jul 2009) ISSN: 1420-9071 [Electronic] Switzerland
• PMID: 19333552 (Publication Type: Journal Article, Review)

Chemical References

• Angiogenesis Inhibitors
• Vascular Endothelial Growth Factor A
• Cyclooxygenase 2
• Matrix Metalloproteinases

Topics

• Angiogenesis Inhibitors (pharmacology)
• Animals
• Cyclooxygenase 2 (metabolism)
• Humans
• Matrix Metalloproteinases (metabolism)
• Neoplasms, Experimental (blood supply, drug therapy)
• Neovascularization, Pathologic (drug therapy)
• Photochemotherapy
• Vascular Endothelial Growth Factor A (metabolism)