Adhesion/growth-regulatory tissue lectin galectin-1 in relation to angiogenesis/lymphocyte infiltration and prognostic relevance of stromal up-regulation in laryngeal carcinomas.

Abstract

BACKGROUND:

Galectin-1 has been found to modulate lymphocyte invasion in inflammation and to be involved in angiogenesis in models, thus prompting examination of its clinical relevance in laryngeal cancer.

PATIENTS AND METHODS:

Immunohistochemical processing of tissue sections (n=53) from patients with stage I/II (n=35) and stage IV (n=18) laryngeal squamous cell carcinoma (LSCC) with a specific anti-galectin-1 antibody and monitoring of CD45/CD31 positivity was combined with quantitative morphometric analysis.

RESULTS:

Lectin presence in the tumor and endothelial cells was positively correlated, while a negative relationship to the number of CD45-positive lymphocytes was demonstrated. No association was seen with the extent of neovascularization. The mean optical density (MOD) of lectin-dependent staining in the tumor stroma was significantly increased compared to normal stroma.

CONCLUSION:

Galectin-1 was not associated with angiogenesis in the studied cohort while galectin-1 in endothelial cells may negatively influence lymphocyte invasion and the mean optical density for the stromal galectin-1 signal is up-regulated in tumors.

• Authors: Sven Saussez, Christine Decaestecker, Stéphanie Cludts, Perle Ernoux, Dominique Chevalier, Karel Smetana Jr, Sabine André, Xavier Leroy, Hans-Joachim Gabius
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 1 Pg. 59-65 (Jan 2009) ISSN: 0250-7005 [Print] Greece
• PMID: 19331133 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Galectin 1
• LGALS1 protein, human

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (blood supply, immunology, pathology)
• Female
• Galectin 1 (biosynthesis, genetics, immunology, physiology)
• Humans
• Laryngeal Neoplasms (blood supply, immunology, pathology)
• Lymphocyte Activation
• Lymphocytes, Tumor-Infiltrating (immunology, pathology)
• Male
• Middle Aged
• Neovascularization, Pathologic (metabolism, pathology)
• Prognosis
• Stromal Cells (immunology, metabolism, pathology)
• Up-Regulation