Abstract |
The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.
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Authors | E K Tan, C S Lu, R Peng, Y Y Teo, Y H Wu-Chou, R S Chen, Y H Weng, C M Chen, H C Fung, L C Tan, Z J Zhang, X K An, G J Lee-Chen, M C Lee, S Fook-Chong, J M Burgunder, R M Wu, Y R Wu |
Journal | Neurobiology of aging
(Neurobiol Aging)
Vol. 31
Issue 12
Pg. 2194-6
(Dec 2010)
ISSN: 1558-1497 [Electronic] United States |
PMID | 19329225
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2008 Elsevier Inc. All rights reserved. |
Chemical References |
- UCHL1 protein, human
- Ubiquitin Thiolesterase
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Topics |
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Asian People
(ethnology, genetics)
- Female
- Genetic Association Studies
- Genetic Variation
(genetics)
- Humans
- Male
- Middle Aged
- Parkinson Disease
(enzymology, epidemiology, genetics)
- Singapore
(epidemiology, ethnology)
- Taiwan
(epidemiology, ethnology)
- Ubiquitin Thiolesterase
(genetics)
- Ubiquitination
(genetics)
- Young Adult
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