Abstract | BACKGROUND: METHODS: An angiography-based case-control study was conducted, including 300 sex- and age-matched subjects [100 CAD-free, 100 CAD without myocardial infarction (MI) and 100 CAD with MI]. RESULTS: A low DEPCyMCase activity (lowest vs. highest tertile: OR 2.96, 95% CI 1.18-7.43) and a high NLA (highest vs. lowest tertile: OR 3.25, 95% CI 1.28-8.26) were both associated with CAD, independent of classical atherosclerosis risk factors, lipid-lowering therapy and PON1 genotype. Total TBBLase activity was, however, not different in CAD compared to CAD-free subjects. CONCLUSIONS: Novel PON1 activity assays may be associated with CAD. In this study, CAD patients had low DEPCyMCase activity, a possible marker of low PON1 concentration, but showed a high stimulation of PON1 lactonase activity.
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Authors | Nicola Martinelli, Domenico Girelli, Oliviero Olivieri, Patrizia Guarini, Antonella Bassi, Elisabetta Trabetti, Simonetta Friso, Francesca Pizzolo, Claudia Bozzini, Ilaria Tenuti, Laura Annarumma, Renzo Schiavon, Pier Franco Pignatti, Roberto Corrocher |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 47
Issue 4
Pg. 432-40
( 2009)
ISSN: 1434-6621 [Print] Germany |
PMID | 19275503
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aryldialkylphosphatase
(metabolism)
- Coronary Artery Disease
(blood, diagnosis, enzymology)
- Female
- Humans
- Immunoassay
(methods)
- Male
- Middle Aged
- Risk Factors
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