Fibrin glue reduces the duration of lymphatic drainage after lumpectomy and level II or III axillary lymph node dissection for breast cancer: a prospective randomized trial.

Abstract

This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output after lumpectomy and axillary dissection in breast cancer patients. A total of 100 patients undergoing breast lumpectomy and axillary dissection were randomized to a fibrin glue group (N=50; glue sprayed onto the axillary dissection site) or a control group (N=50). Outcome measures were drainage duration, overall drain output, and incidence of seroma. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of seroma. However, subgroup analysis showed that fibrin glue use resulted in a shorter drainage duration (3.5 vs. 4.7 days; p=0.0006) and overall drain output (196 vs. 278 mL; p=0.0255) in patients undergoing level II or III axillary dissection. Fibrin glue use reduced drainage duration and overall drain output in breast cancer patients undergoing a lumpectomy and level II or III axillary dissection.

• Authors: Eunyoung Ko, Wonshik Han, Jihyoung Cho, Jong Won Lee, So Young Kang, So-Youn Jung, Eun-Kyu Kim, Ki-Tae Hwang, Dong-Young Noh
• Journal: Journal of Korean medical science (J Korean Med Sci) Vol. 24 Issue 1 Pg. 92-6 (Feb 2009) ISSN: 1598-6357 [Electronic] Korea (South)
• PMID: 19270819 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Fibrin Tissue Adhesive
• Tissue Adhesives

Topics

• Adult
• Axilla
• Breast Neoplasms (pathology, surgery)
• Drainage
• Female
• Fibrin Tissue Adhesive (therapeutic use)
• Humans
• Lymph Node Excision
• Mastectomy, Segmental
• Middle Aged
• Prospective Studies
• Seroma (epidemiology, etiology)
• Severity of Illness Index
• Time Factors
• Tissue Adhesives (therapeutic use)