Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

Abstract

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

• Authors: Christine L E Siezen, Louis Bont, Hennie M Hodemaekers, Marieke J Ermers, Gerda Doornbos, Ruben Van't Slot, Ciska Wijmenga, Hans C van Houwelingen, Jan L L Kimpen, Tjeerd G Kimman, Barbara Hoebee, Riny Janssen
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 28 Issue 4 Pg. 333-5 (Apr 2009) ISSN: 0891-3668 [Print] United States
• PMID: 19258923 (Publication Type: Journal Article)

Chemical References

• Receptors, Transforming Growth Factor beta
• Protein Serine-Threonine Kinases
• Receptor, Transforming Growth Factor-beta Type I
• TGFBR1 protein, human
• ADAM Proteins
• ADAM33 protein, human

Topics

• ADAM Proteins (genetics)
• Bronchiolitis, Viral (genetics)
• Cohort Studies
• Data Interpretation, Statistical
• Genetic Predisposition to Disease
• Humans
• Immunity, Innate (genetics)
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (genetics)
• Lung (growth & development)
• Polymorphism, Single Nucleotide
• Protein Serine-Threonine Kinases (genetics)
• Receptor, Transforming Growth Factor-beta Type I
• Receptors, Transforming Growth Factor beta (genetics)
• Respiratory Syncytial Virus Infections (genetics)
• Risk Factors