Abstract | BACKGROUND: METHODS: Consecutive patients (total 200; 124 males, 76 females; mean age, 71.4 years) with acute ischemic stroke within 24 hours of onset were prospectively enrolled. We measured plasma BNP on admission. Patients were divided into four groups according to the TOAST classification: large-vessel disease (LVD), cardioembolism (CE), small-vessel disease (SVD), and other stroke. Correlation between plasma BNP level and stroke subtype was then examined. RESULTS: Cardioembolism (41%) was the most frequent stroke subtype, followed by other stroke (34%), SVD (16%), and LVD (9%). Age, female, atrial fibrillation, NIHSS score > or = 7 on admission and mRS score > or = 3 at discharge were significantly higher in CE than in the other stroke subtypes. The mean plasma BNP level of the CE group was significantly higher than that of the other 3 subtypes (409.6 pg/mL for CE, 94.0 pg/mL for LVD, 37.4 pg/mL for SVD, and 156.9 pg/mL for others, p<0.001). The optimal cut-off concentration, sensitivity, and specificity of plasma BNP levels to distinguish CE from other stroke subtypes were 140.0 pg/mL, 80.5% and 80.5%, respectively. CONCLUSION: Plasma BNP level is significantly higher in CE patients than in other stroke subtypes, and thus physicians should strongly consider CE when the plasma BNP level is over 140.0 pg/mL in patients with acute ischemic stroke.
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Authors | Kensaku Shibazaki, Kazumi Kimura, Yasuyuki Iguchi, Yoko Okada, Takeshi Inoue |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 48
Issue 5
Pg. 259-64
( 2009)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 19252345
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Natriuretic Peptide, Brain
|
Topics |
- Aged
- Aged, 80 and over
- Algorithms
- Biomarkers
(blood)
- Diagnosis, Differential
- Female
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Prospective Studies
- ROC Curve
- Sensitivity and Specificity
- Stroke
(blood, classification, diagnosis)
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