[A case of metastatic pancreatic cancer after combination chemotherapy with uracil-tegafur and gemcitabine].

Abstract

We report a case of pancreas head cancer with liver metastasis treated with uracil-tegafur (UFT) and gemcitabine combined chemotherapy. A 66-year-old man was referred to our hospital for obstructive jaundice. We planned to perform a pancreatoduodenectomy, but a small nodule was found at laparotomy on the liver surface. The histopathological diagnosis was adenocarcinoma, so we inserted a self-expandable metallic stent (EMS) in this inoperable pancreas head cancer. We performed 9 courses of UFT and gemcitabine (GEM) combination chemotherapy. Renewed liver metastases did not appear, and the pancreas head tumor partially responded. Pancreatoduodenectomy was performed, and EMS could not be separated from the common bile duct. After treatment with an additional 11 courses of chemotherapy, he took S-1 orally because of a tumor recurrence. He survived for 24 months from the first laparotomy. Combination chemotherapy and surgery enhanced the survival benefit in this case.

• Authors: Keishi Sugimoto, Kaoru Okada, Shin Nakahira, Shu Okamura, Hirofumi Miki, Ken Nakata, Rei Suzuki, Mio Yoshimura, Kumiko Uji, Atsuko Yoshida, Shigeyuki Tamura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 2 Pg. 321-3 (Feb 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19223756 (Publication Type: Case Reports, Journal Article)

Chemical References

• Deoxycytidine
• Tegafur
• Uracil
• Gemcitabine

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Fatal Outcome
• Humans
• Liver Neoplasms (diagnostic imaging, drug therapy, secondary, surgery)
• Male
• Pancreatic Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Tegafur (therapeutic use)
• Tomography, X-Ray Computed
• Uracil (therapeutic use)
• Gemcitabine