MYO9B polymorphisms in multiple sclerosis.

Abstract

Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.

• Authors: Anu Kemppinen, Minna Suvela, Pentti J Tienari, Irina Elovaara, Keijo Koivisto, Tuula Pirttilä, Mauri Reunanen, Ilkka Rautakorpi, Jan Hillert, Frida Lundmark, Annette Oturai, Lars Ryder, Hanne F Harbo, Elisabeth G Celius, Aarno Palotie, Mark Daly, Leena Peltonen, Janna Saarela
• Journal: European journal of human genetics : EJHG (Eur J Hum Genet) Vol. 17 Issue 6 Pg. 840-3 (Jun 2009) ISSN: 1476-5438 [Electronic] England
• PMID: 19142207 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• myosin IXB
• Myosins

Topics

• Case-Control Studies
• Family
• Genotype
• Humans
• Multiple Sclerosis (genetics)
• Myosins (genetics)
• Polymorphism, Genetic (genetics)
• White People (genetics)