Abstract | BACKGROUND: METHODS: Between December 2003 and May 2004, 209 patients with endoscopically and histologically proven Barrett's esophagus were enrolled. Before endoscopic examination, all participants answered structured questionnaires for gastroesophageal reflux symptoms and drug usage. HIF-1alpha and COX-2 protein expressions, cellular proliferation, and apoptosis were investigated immunohistochemically in biopsy samples taken from the esophagus of each patient. The degree of angiogenesis was determined by CD34 immunostaining analysis. Predictors for angiogenesis were evaluated with multivariate logistic regression analysis. RESULTS: CONCLUSIONS:
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Authors | Nobuyuki Moriyama, Yuji Amano, Yuko Mishima, Koichi Okita, Yoshiko Takahashi, Takafumi Yuki, Norihisa Ishimura, Shunji Ishihara, Yoshikazu Kinoshita |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 23 Suppl 2
Pg. S210-5
(Dec 2008)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 19120900
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD34
- HIF1A protein, human
- Hypoxia-Inducible Factor 1, alpha Subunit
- Proliferating Cell Nuclear Antigen
- Cyclooxygenase 2
- PTGS2 protein, human
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Topics |
- Aged
- Antigens, CD34
(analysis)
- Apoptosis
- Barrett Esophagus
(metabolism, pathology)
- Cell Proliferation
- Cyclooxygenase 2
(analysis)
- Esophagitis, Peptic
(pathology, physiopathology)
- Esophagoscopy
- Female
- Gastroesophageal Reflux
(pathology, physiopathology)
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
(analysis)
- Immunohistochemistry
- Logistic Models
- Male
- Middle Aged
- Neovascularization, Pathologic
(metabolism, pathology)
- Odds Ratio
- Proliferating Cell Nuclear Antigen
(analysis)
- Risk Assessment
- Risk Factors
- Stromal Cells
(chemistry, pathology)
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