Abstract |
The expression of the gut intra-epithelial T-cell associated molecule HML-1, a trimeric protein of 150, 125, 105 kD, was studied in 75 T-cell lymphomas of different subtypes: 20 T-lymphoblastic lymphomas/leukaemias; 50 nodal peripheral T-cell lymphomas; and five intestinal T-cell lymphomas. Our results confirm: (i) the usefulness of the HML-1 monoclonal antibody as an immunohistochemical marker for intestinal T-cell lymphomas: and (ii) the lack of reactivity of HML-1 with nodal peripheral T-cell lymphomas. Moreover, expression of the HML-1 molecule was found for the first time in a case of T- lymphoblastic lymphoma/leukaemia. The patient presented with a mediastinal mass which consisted of HML-1 + neoplastic cells displaying a phenotypic profile consistent with early thymocytes. Genes coding for the alpha, beta, gamma and delta chains of the T-cell receptor were in a germline configuration. The neoplastic cells could have been derived from the small subset of HML-1 + thymocytes detectable in the cortex of normal human thymus.
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Authors | B Falini, L Flenghi, M Fagioli, P G Pelicci, H Stein, B Bigerna, S Pileri, M F Martelli |
Journal | Histopathology
(Histopathology)
Vol. 18
Issue 5
Pg. 421-6
(May 1991)
ISSN: 0309-0167 [Print] England |
PMID | 1909296
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Neoplasm
- Biomarkers, Tumor
- CD8 Antigens
- Integrins
- Receptors, Interleukin-2
- integrin alphaEbeta7
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Topics |
- Adolescent
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
(analysis)
- Antigens, Neoplasm
(analysis)
- Biomarkers, Tumor
(analysis)
- Blotting, Southern
- CD8 Antigens
- Humans
- Integrins
- Intestinal Neoplasms
(immunology)
- Lymphoma, T-Cell
(immunology)
- Male
- Mediastinal Neoplasms
(immunology)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(immunology)
- Receptors, Interleukin-2
(analysis)
- T-Lymphocytes
(immunology)
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