Abstract | BACKGROUND: MATERIALS AND METHODS: In the present study, 131 keratocystic odontogenic tumors were analyzed by immunohistochemistry for the expression of sonic hedgehog signaling proteins SHH, PTCH1, SMO, GLI1, and NMYC on tissue microarray sections. RESULTS: High expression of the analyzed proteins-between 67.3% (PTCH1) and 92.9% (SHH)-was found in the epithelial compartment of the keratocystic odontogenic tumors analyzed. In the stromal compartment of the tumors, high expression of the target proteins was found significantly less frequently (all p-values <0.001). CONCLUSION: Aberrant sonic hedgehog signaling is critically involved in the molecular pathogenesis of keratocystic odontogenic tumors. This finding underlines the neoplastic character of this intraosseous lesion. Because of high recurrence rates after local excision, more radical surgical approaches are recommended for treating keratocystic odontogenic tumors.
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Authors | K Freier, S Pungs, C Flechtenmacher, C Hofele |
Journal | HNO
(HNO)
Vol. 57
Issue 4
Pg. 345-50
(Apr 2009)
ISSN: 1433-0458 [Electronic] Germany |
Vernacular Title | Aktivierung des Sonic-hedgehog-Signalwegs in keratozystischen odontogenen Tumoren. |
PMID | 19082818
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Gene Expression Regulation, Neoplastic
- Hedgehog Proteins
(metabolism)
- Humans
- Jaw Neoplasms
(metabolism)
- Odontogenic Cysts
(metabolism)
- Odontogenic Tumors
(metabolism)
- Signal Transduction
- Tumor Cells, Cultured
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