Abstract | AIM: To evaluate the effectiveness of accumulation phase, fat-suppressed, T1-weighted imaging (FS-T1WI) when detecting hepatocellular carcinoma (HCC) by ferucarbotran-enhanced magnetic resonance imaging (MRI). MATERIALS AND METHODS: Thirty patients who underwent ferucarbotran-enhanced MRI, which resulted in 35 confirmed HCCs, were included in this prospective study. Two image sets were prepared and two radiologists independently reviewed these in two reading sessions; set A was without contrast-enhanced accumulation phase FS-T1WI and set B included contrast-enhanced accumulation phase FS-T1WI. All HCCs had been confirmed by operation (n=4), by biopsy (n=28), and by follow-up study for at least 1 year (n=3). RESULTS: The contrast-to-noise ratio significantly increased from -1.2+/-7.5 to 12.7+/-7.3 with contrast-enhanced accumulation phase FS-T1WI, but was only slightly increased from 12.2+/-10.3 to 15.5+/-12.2 with contrast-enhanced T2WI (p<0.001). The signal-to-noise ratio (SNR) was decreased with T1WI and T2WI for liver parenchyma. With T2WI, the SNR for HCCs was decreased; however, it was slightly increased with T1WI (p<0.001). Overall, 29 HCCs were detected using set A, and 35 nodules were identified using set B, which included the contrast-enhanced accumulation phase FS-T1WI. Thus, the detection rate significantly increased using post-contrast medium accumulation phase FS-T1WI (p<0.05). CONCLUSION: Due to the improved CNR with the post-contrast medium accumulation phase FS-T1WI, which helped to increase HCC detection, accumulation phase FS-T1WI is recommended as one of the routine protocols for inclusion in HCC detection.
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Authors | C-T Chou, R-C Chen, W-T Chen, J-M Lii |
Journal | Clinical radiology
(Clin Radiol)
Vol. 64
Issue 1
Pg. 22-9
(Jan 2009)
ISSN: 1365-229X [Electronic] England |
PMID | 19070694
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Contrast Media
- Dextrans
- Magnetite Nanoparticles
- Oxides
- Iron
- ferumoxides
- Ferrosoferric Oxide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Hepatocellular
(diagnosis)
- Contrast Media
- Dextrans
- Female
- Ferrosoferric Oxide
- Humans
- Image Interpretation, Computer-Assisted
(methods)
- Iron
- Liver Neoplasms
(diagnosis)
- Magnetic Resonance Imaging
(methods)
- Magnetite Nanoparticles
- Male
- Middle Aged
- Oxides
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