A 71-year-old woman was admitted with
fever up and
weight loss. Abdominal computed tomography (CT) revealed right renal
tumor 7 cm in diameter and inferior vena caval
thrombus and multiple
lymph node metastases and lung
metastases. Transabdominal right
nephrectomy and
thrombectomy was performed and pathological examination was
renal cell carcinoma (clear cell
carcinoma, G3, INFbeta, v (+), pT3b, pN2) with adrenal invasion and
lymph node metastases. She received 600 x 10(4) IU/day of
interferon alpha (IFN-alpha) intramuscularly 3 times a week for 16 weeks from the 20th post-operative day. The disease showed progression and liver
metastases 5 cm in diameter appeared. Then she received 140 x 10(4) JRU/day of
IL-2 (div) 5 times a week for 4 weeks. CT showed a complete response on lung
metastases and
lymph node metastases and marked decrease of liver
metastases after the first course of
IL-2. After the second course, the liver mass remained 2 cm in diameter and then
radiofrequency ablation (RFA) under CT was performed. CT after RFA showed a low density area at the liver
tumor without enhancement. About five years after the operation, she is alive without evidence of disease.