Abstract | AIM: METHODS: The study population consisted of children aged 6 months to 14 years. At the time of visit to the hospital, the children had fever; the cause of fever was determined to be URTI by a paediatrician based on history taking and physical examination. The study was a multicentre, randomized, double-blind, controlled parallel group, comparative, Phase 3 clinical trial, conducted at three hospitals. By using a computer-based random assignment program, the subjects were allocated to the following three groups: 5 mg kg(-1) dexibuprofen group, 7 mg kg(-1) dexibuprofen group, and 10 mg kg(-1) ibuprofen group. RESULTS: CONCLUSIONS:
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Authors | Jong Seo Yoon, Dae-Chul Jeong, Jae-Won Oh, Keun Young Lee, Hyun Seung Lee, Young Yull Koh, Jin Tack Kim, Jin Han Kang, Joon Sung Lee |
Journal | British journal of clinical pharmacology
(Br J Clin Pharmacol)
Vol. 66
Issue 6
Pg. 854-60
(Dec 2008)
ISSN: 1365-2125 [Electronic] England |
PMID | 19032727
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- dexibuprofen
- Ibuprofen
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Topics |
- Administration, Oral
- Adolescent
- Analysis of Variance
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacokinetics)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Fever
(drug therapy, etiology)
- Humans
- Ibuprofen
(administration & dosage, analogs & derivatives, pharmacokinetics)
- Infant
- Male
- Respiratory Tract Infections
(complications, drug therapy)
- Treatment Outcome
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