Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus.

Abstract

Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus.

• Authors: Maud Lemoine, Aurelie Revaux, Claire Francoz, Guillaume Ducarme, Sabine Brechignac, Emmanuel Jacquemin, Michele Uzan, Nathalie Ganne-Carrie
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 14 Issue 42 Pg. 6572-4 (Nov 14 2008) ISSN: 1007-9327 [Print] United States
• PMID: 19030215 (Publication Type: Case Reports, Journal Article)

Chemical References

• Albumins
• Cholagogues and Choleretics
• Ursodeoxycholic Acid

Topics

• Albumins (therapeutic use)
• Cesarean Section
• Cholagogues and Choleretics (adverse effects)
• Cholestasis, Intrahepatic (complications, therapy)
• Female
• Gestational Age
• Humans
• Infant, Newborn
• Live Birth
• Male
• Pregnancy
• Pregnancy Complications (therapy)
• Pruritus (etiology, therapy)
• Renal Dialysis
• Sorption Detoxification (methods)
• Ursodeoxycholic Acid (adverse effects)
• Young Adult