Abstract |
The effect of glycyrrhizin on inflammatory mediators such as neutrophil functions including reactive oxygen species (ROS) generation was examined. Glycyrrhizin significantly decreased neutrophil-generated O2-, H2O2 and OH in a dose-dependent manner. However, the drug did not reduce any of the ROS generated in a cell-free, xanthine- xanthine oxidase system. The drug did not affect neutrophil chemotaxis or phagocytosis, either. The present study indicates that glycyrrhizin is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting the generation of ROS by neutrophils, the most potent inflammatory mediator at the site of inflammation.
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Authors | H Akamatsu, J Komura, Y Asada, Y Niwa |
Journal | Planta medica
(Planta Med)
Vol. 57
Issue 2
Pg. 119-21
(Apr 1991)
ISSN: 0032-0943 [Print] Germany |
PMID | 1891493
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Free Radicals
- Glycyrrhizic Acid
- Glycyrrhetinic Acid
- Oxygen
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Chemotaxis, Leukocyte
(drug effects)
- Free Radicals
- Glycyrrhetinic Acid
(analogs & derivatives, pharmacology)
- Glycyrrhizic Acid
- Humans
- Neutrophils
(drug effects, metabolism)
- Oxygen
(metabolism)
- Phagocytosis
(drug effects)
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