Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X.

Abstract

Peripheral neuropathy is a well-known side effect of vincristine, a micro-tubule inhibitor commonly used to treat malignancies. Severe neurologic adverse events can occur in patients with Charcot-Marie-Tooth disease (CMT) treated with vincristine. Voriconazole is an antifungal agent used increasingly in children with malignancy. Because of its metabolism by hepatic p450 enzymes, voriconazole may inhibit the clearance of many medications, including vincristine. We report a case of vincristine related neuropathy that was exacerbated by voriconazole in a patient with previously undiagnosed, X-linked CMT.

• Authors: Christopher C Porter, Amy E Carver, Edythe A Albano
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 52 Issue 2 Pg. 298-300 (Feb 2009) ISSN: 1545-5017 [Electronic] United States
• PMID: 18837430 (Publication Type: Case Reports, Journal Article)
• Copyright: (c) 2008 Wiley-Liss, Inc.

Chemical References

• Pyrimidines
• Triazoles
• Vincristine
• Voriconazole

Topics

• Charcot-Marie-Tooth Disease (complications, drug therapy)
• Child, Preschool
• Drug Synergism
• Female
• Humans
• Peripheral Nervous System Diseases (chemically induced)
• Pyrimidines (adverse effects)
• Triazoles (adverse effects)
• Vincristine (adverse effects)
• Voriconazole