[Comparative evaluation of 2 schedules of administration of anti- neoplastic drugs by the CMF protocol in disseminated breast cancer].

Abstract

Combined chemotherapy with cyclophosphamide, methotrexate, fluorouracil (CMF) in two regimens of administration was comparatively assessed in a randomized and prospective trial. Group I patients (n = 34) received methotrexate and fluorouracil once a week and cyclophosphamide every other day for 15 days. In group II (n = 32) all the drugs were given simultaneously once weekly for 15 days. A complete and partial response occurred significantly more frequently in patients of group I (36%) versus group II (7%). The intergroup difference in toxicity appeared insignificant.

• Authors: D B Korman, V A Snimshchikov, L B Dobroskok, I A Maslova, S G Mikaélian, E V Pines
• Journal: Sovetskaia meditsina (Sov Med) Issue 3 Pg. 14-5 ( 1991) ISSN: 0038-5077 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka dvukh rezhimov vvedeniia protivoopukholevykh preparatov po skheme CMF pri disseminirovannom rake molochnoĭ zhelezy.
• PMID: 1882280 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Cisplatin
• Fluorouracil
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Neoplasms (drug therapy, etiology, secondary)
• Breast Neoplasms (drug therapy, pathology)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Humans
• Liver Neoplasms (drug therapy, etiology, secondary)
• Methotrexate (administration & dosage)
• Prospective Studies
• Remission Induction