Adhesion molecules in lung cancer: implications in the pathogenesis and management.

Abstract

Growth and metastasis of lung cancer requires a sequence of events, which alter the ability of neoplastic cells to adhere to themselves, to normal surrounding cells, or to the extracellular matrix. Interactions between cells are primarily mediated by four types of structures in the plasma membrane: gap junctions, tight junctions, desmosomes, and adherence junctions. We have reviewed the existing data on the implication of adhesion molecules in the pathogenesis of lung cancer, as well as the application of certain adhesion molecules as potential surrogate markers in lung cancer patients.

• Authors: Kostas N Syrigos, Nikos Katirtzoglou, Elias Kotteas, Kevin Harrington
• Journal: Current pharmaceutical design (Curr Pharm Des) Vol. 14 Issue 22 Pg. 2173-83 ( 2008) ISSN: 1873-4286 [Electronic] United Arab Emirates
• PMID: 18781970 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Biomarkers
• Cell Adhesion Molecules

Topics

• Antineoplastic Agents (pharmacology)
• Biomarkers
• Cell Adhesion Molecules (metabolism)
• Drug Design
• Humans
• Lung Neoplasms (drug therapy, metabolism)