Abstract | OBJECTIVE: To establish whether serum uric acid concentration correlates with carotid intima-media wall thickness (IMT) in a cohort of psoriatic arthritis (PsA) patients without overt cardiovascular (CV) disease or classic CV risk factors who attended a community hospital. METHODS: A series of 52 PsA patients were assessed by carotid ultrasonography. Carotid IMT and carotid plaques were measured in the right common carotid artery. A correlation between serum uric acid concentration and carotid IMT was assessed and receiver operating characteristic curves to evaluate the ability of serum uric acid to predict carotid IMT > 0.90 mm and carotid plaques were performed. RESULTS: PsA patients with hyperuricemia (n = 6 [11.5%]) had greater carotid IMT (mean +/- standard deviation: 0.89 +/- 0.20 mm) than those without hyperuricemia (n = 46 [89%]; 0.67 +/- 0.16 mm) (P = 0.01). Patients with carotid IMT < 0.60 mm had lower mean serum uric acid levels (4.7 +/- 1.2 mg/dL) than those with greater carotid IMT (5.3 +/- 1.7 mg/dL for patients with carotid IMT 0.76-0.90 mm and 6.4 +/- 1.3 mg/dL for those with carotid IMT > 0.90 mm; P for trend = 0.02). A significant correlation between carotid IMT and serum uric acid concentration was observed (r = 0.337; P = 0.01). High serum uric acid levels were associated with an increased risk of having carotid IMT > 0.90 mm (Odds ratio = 2.66 [95% confidence interval: 1.08-6.53], P = 0.03, area under receiver operating characteristic curve: 0.80) or with the presence of carotid plaques (Odds ratio = 1.85 [95%; confidence interval: 1.01-3.38], P = 0.05, area under receiver operating characteristic curve: 0.72). CONCLUSIONS: In PsA patients without clinically evident CV disease there is a correlation between serum uric acid concentration and subclinical atherosclerosis.
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Authors | Miguel A Gonzalez-Gay, Carlos Gonzalez-Juanatey, Tomas R Vazquez-Rodriguez, Ines Gomez-Acebo, Jose A Miranda-Filloy, Jose Paz-Carreira, Javier Martin, Javier Llorca |
Journal | Seminars in arthritis and rheumatism
(Semin Arthritis Rheum)
Vol. 39
Issue 3
Pg. 157-62
(Dec 2009)
ISSN: 1532-866X [Electronic] United States |
PMID | 18722649
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Arthritis, Psoriatic
(blood, complications)
- Atherosclerosis
(blood, diagnostic imaging, epidemiology)
- Biomarkers
(blood)
- Carotid Arteries
(diagnostic imaging)
- Cohort Studies
- Female
- Humans
- Hyperuricemia
(blood)
- Male
- Middle Aged
- ROC Curve
- Risk Factors
- Tunica Intima
(diagnostic imaging)
- Tunica Media
(diagnostic imaging)
- Ultrasonography
- Uric Acid
(blood)
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