Abstract | AIM OF THE STUDY: MATERIALS AND METHODS: We measured red blood cell content of eicosapentaenoic acid (EPA)+ docosahexaenoic acid (DHA) expressed as a percentage of total FAs (the omega-3 index) at admission in 460 patients hospitalised with an acute coronary syndrome. Out of 265 patients suffering their first MI, 10 (cases) experienced an episode of VF during the initial 6h of symptom onset. The omega-3 index of these patients was compared to that of 185 first-MI patients (controls) free of VF for at least 30 days post-admission. RESULTS: The median value of the omega-3 index in the VF cases was 4.88% as compared to 6.08% in the controls (p=0.013). After adjustment for age, sex, ejection fraction, high-sensitivity C-reactive protein, use of beta-blocker, differences of infarct characteristics and previous angina pectoris, a 1% increase of the omega-3 index was associated with a 48% reduction in risk of VF (odds ratio (OR) 0.52, 95% confidence interval (CI) 0.28-0.96; p=0.037). CONCLUSION: Our study supports an anti-arrhythmic effect of n-3 FAs through their incorporation into myocardial cell membranes, reducing the risk of VF during ischaemia.
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Authors | Hildegunn Aarsetøy, Volker Pönitz, Odd Bjarte Nilsen, Heidi Grundt, William S Harris, Dennis W T Nilsen |
Journal | Resuscitation
(Resuscitation)
Vol. 78
Issue 3
Pg. 258-64
(Sep 2008)
ISSN: 0300-9572 [Print] Ireland |
PMID | 18556107
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
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Topics |
- Aged
- Case-Control Studies
- Cohort Studies
- Docosahexaenoic Acids
(blood)
- Eicosapentaenoic Acid
(blood)
- Female
- Hospitalization
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, complications, therapy)
- Risk Factors
- Ventricular Fibrillation
(blood, etiology, therapy)
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