Abstract | BACKGROUND: METHODS: Participants (n = 272) were subjects who consented to the pharmacogenetic analysis of a multi-site, randomized, placebo-controlled trial of targeted nalmefene for the reduction of heavy drinking. We genotyped two single nucleotide polymorphisms (SNPs) in OPRM1 (including A118G, a commonly studied SNP that encodes an Asn40Asp amino acid substitution), two SNPs in OPRD1, and one SNP in OPRK1, which encode the mu-, delta-, and kappa-opioid receptors, respectively. Regression analysis served to examine the moderating effects of these SNPs on medication response. RESULTS: As previously described by Karhuvaara et al. (2007), nalmefene significantly reduced the number of heavy drinking and very heavy drinking days per week, compared with placebo. There were no main or moderating effects of the genotypes examined on these outcomes. CONCLUSIONS:
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Authors | Albert J Arias, Stephen Armeli, Joel Gelernter, Jonathan Covault, Antero Kallio, Sakari Karhuvaara, Tiina Koivisto, Rauno Mäkelä, Henry R Kranzler |
Journal | Alcoholism, clinical and experimental research
(Alcohol Clin Exp Res)
Vol. 32
Issue 7
Pg. 1159-66
(Jul 2008)
ISSN: 1530-0277 [Electronic] England |
PMID | 18537939
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Narcotic Antagonists
- Receptors, Opioid
- Naltrexone
- nalmefene
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Topics |
- Adult
- Alcohol-Related Disorders
(drug therapy, genetics)
- Female
- Humans
- Male
- Middle Aged
- Naltrexone
(analogs & derivatives, therapeutic use)
- Narcotic Antagonists
(therapeutic use)
- Polymorphism, Single Nucleotide
- Randomized Controlled Trials as Topic
- Receptors, Opioid
(genetics)
- Treatment Outcome
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