Abstract | BACKGROUND: METHODS: RESULTS: A total of 2452 patients were randomly assigned to a treatment group. Significantly more patients had early ST-segment resolution with combination-facilitated PCI (43.9%) than with abciximab-facilitated PCI (33.1%) or primary PCI (31.0%; P=0.01 and P=0.003, respectively). The primary end point occurred in 9.8%, 10.5%, and 10.7% of the patients in the combination-facilitated PCI group, abciximab-facilitated PCI group, and primary-PCI group, respectively (P=0.55); 90-day mortality rates were 5.2%, 5.5%, and 4.5%, respectively (P=0.49). CONCLUSIONS:
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Authors | Stephen G Ellis, Michal Tendera, Mark A de Belder, Ad J van Boven, Petr Widimsky, Luc Janssens, H R Andersen, Amadeo Betriu, Stefano Savonitto, Jerzy Adamus, Jan Z Peruga, Maciej Kosmider, Olivier Katz, Thomas Neunteufl, Julia Jorgova, Maria Dorobantu, Liliana Grinfeld, Paul Armstrong, Bruce R Brodie, Howard C Herrmann, Gilles Montalescot, Franz-Josef Neumann, Mark B Effron, Elliot S Barnathan, Eric J Topol, FINESSE Investigators |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 358
Issue 21
Pg. 2205-17
(May 22 2008)
ISSN: 1533-4406 [Electronic] United States |
PMID | 18499565
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2008 Massachusetts Medical Society. |
Chemical References |
- Antibodies, Monoclonal
- Fibrinolytic Agents
- Immunoglobulin Fab Fragments
- Recombinant Proteins
- reteplase
- Tissue Plasminogen Activator
- Abciximab
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Topics |
- Abciximab
- Aged
- Angioplasty, Balloon, Coronary
- Antibodies, Monoclonal
(adverse effects, therapeutic use)
- Cerebral Infarction
(chemically induced)
- Combined Modality Therapy
- Double-Blind Method
- Electrocardiography
- Female
- Fibrinolytic Agents
(administration & dosage, adverse effects)
- Hemorrhage
(chemically induced)
- Humans
- Immunoglobulin Fab Fragments
(adverse effects, therapeutic use)
- Kaplan-Meier Estimate
- Male
- Myocardial Infarction
(classification, complications, mortality, therapy)
- Recombinant Proteins
(administration & dosage, adverse effects)
- Time Factors
- Tissue Plasminogen Activator
(administration & dosage, adverse effects)
- Treatment Outcome
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