Abstract | BACKGROUND/AIMS: METHODS: Patients who were diagnosed as ERD by one gastroenterologist at the Kangnam St. Mary's hospital were prospectively enrolled. The persons without ERD in the control group were matched for age and sex. We examined the gastrin, pepsinogen I (PG I), PG II, PG I/II ratio, and H. pylori infection. RESULTS: Forty five patients were enrolled in ERD group and 66 persons in control group. The H. pylori infection rate in ERD group was lower than that in the control group (11.1% vs. 43.9%, p<0.001). PG I/II ratio in ERD group was higher than that in the control group (7.0+/-3.1 vs. 5.3+/-2.6, p=0.003). The PG II (p=0.016) and gastrin (p=0.029) in ERD group were lower than those in the control group. BMI in ERD group was higher than that in the control group (24.5 vs. 23.1 kg/m2, p=0.013). CONCLUSIONS: The H. pylori infection rate in ERD group was lower and PG I/II ratio was higher than that in the control group. Reflux esophagitis is thought to be reversely associated with the atrophy of gastric mucosa.
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Authors | Jung Hyun Kwon, In-Sik Chung, Hye Suk Son, Jae Myung Park, Yu Kyung Cho, In Seok Lee, Sang Woo Kim, Myung Gyu Choi |
Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
(Korean J Gastroenterol)
Vol. 51
Issue 3
Pg. 159-66
(Mar 2008)
ISSN: 1598-9992 [Print] Korea (South) |
PMID | 18451689
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Chi-Square Distribution
- Esophagitis, Peptic
(diagnosis, microbiology)
- Female
- Gastrins
(blood)
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Pepsinogens
(blood)
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