Synergy of human immunodeficiency virus protease inhibitors with chloroquine against Plasmodium falciparum in vitro and Plasmodium chabaudi in vivo.

Abstract

The synergy of the activities between chloroquine and various human immunodeficiency virus protease inhibitors was investigated in chloroquine-resistant and -sensitive malaria parasites. In both in vitro and in vivo assay systems, ritonavir was found to be the most potent in potentiating the antimalarial action of chloroquine.

• Authors: Zhengxiang He, Li Qin, Lili Chen, Nanzheng Peng, Jianlan You, Xiaoping Chen
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 52 Issue 7 Pg. 2653-6 (Jul 2008) ISSN: 1098-6596 [Electronic] United States
• PMID: 18443126 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• HIV Protease Inhibitors
• Oligopeptides
• Pyridines
• Pyrimidinones
• Lopinavir
• Atazanavir Sulfate
• Chloroquine
• Nelfinavir
• Saquinavir
• Ritonavir

Topics

• Animals
• Antimalarials (administration & dosage)
• Atazanavir Sulfate
• Chloroquine (administration & dosage)
• Drug Resistance
• Drug Synergism
• Female
• HIV Protease Inhibitors (administration & dosage)
• Humans
• In Vitro Techniques
• Lopinavir
• Malaria (drug therapy, parasitology)
• Mice
• Nelfinavir (administration & dosage)
• Oligopeptides (administration & dosage)
• Plasmodium chabaudi (drug effects)
• Plasmodium falciparum (drug effects, growth & development)
• Pyridines (administration & dosage)
• Pyrimidinones (administration & dosage)
• Ritonavir (administration & dosage)
• Saquinavir (administration & dosage)