Antioxidant therapy in male infertility.

Abstract

Although reports have suggested the benefit of antioxidant treatment of infertile men, many studies also show no effect. Most studies in the literature are not randomized, placebo controlled, or double blinded in design, which makes it difficult to differentiate regression toward the mean from true positive treatment effects. The small patient sample sizes and varying male populations also add to the difficulty in comparing studies. Pregnancy, the most relevant outcome parameter, is rarely reported. Ideally, patients would be selected based on oxidative stress levels, and improvement in these levels would be correlated to improvement in pregnancy rates. Until those studies are performed, the use of antioxidants for the treatment of male infertility remains empiric.

• Authors: Sutchin R Patel, Mark Sigman
• Journal: The Urologic clinics of North America (Urol Clin North Am) Vol. 35 Issue 2 Pg. 319-30, x (May 2008) ISSN: 0094-0143 [Print] United States
• PMID: 18423251 (Publication Type: Journal Article, Review)

Chemical References

• Antioxidants

Topics

• Antioxidants (therapeutic use)
• Humans
• Infertility, Male (drug therapy, etiology, metabolism)
• Male
• Oxidative Stress