Successful treatment with multiple intra-articular injections of infliximab in a patient with psoriatic arthritis.

Abstract

This case report presents the clinical and radiographic course of temporomandibular joint (TMJ) involvement in a patient with severe TMJ symptoms from psoriatic arthritis (PsA) resistant to both systemic infliximab and intra-articular glucocorticoid and who therefore received multiple intra-articular infliximab injections for 36 weeks. TMJ symptoms improved after the first bilateral intra-articular infliximab injections but even more so after the second injections. The considerable improvement remained for the 36 weeks studied. Bilateral computerized tomography showed no progression in radiographic changes during the treatment. No adverse reaction was observed from the intra-articular injections.

• Authors: P Alstergren, P T Larsson, S Kopp
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) 2008 Mar-Apr Vol. 37 Issue 2 Pg. 155-7 ISSN: 0300-9742 [Print] England
• PMID: 18415775 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antirheumatic Agents
• Infliximab

Topics

• Antibodies, Monoclonal (administration & dosage, adverse effects, therapeutic use)
• Antirheumatic Agents (administration & dosage, adverse effects, therapeutic use)
• Arthritis, Psoriatic (diagnostic imaging, drug therapy)
• Dose-Response Relationship, Drug
• Female
• Humans
• Infliximab
• Injections, Intra-Articular
• Middle Aged
• Radiography
• Temporomandibular Joint (diagnostic imaging)
• Treatment Outcome