Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab.

Abstract

Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity. The long-term effectiveness and toxicity of this strategy, however, is unknown. In this prospective study, we analyzed our 8-year experience. Patients received a conditioning regimen of fludarabine (30 mg/m(2) daily for 3 days), cyclophosphamide (750 mg/m(2) daily for 3 days), and rituximab (375 mg/m(2) for 1 day plus 1000 mg/m(2) for 3 days). They were then given an infusion of human leukocyte antigen-matched hematopoietic cells from related (n = 45) or unrelated donors (n = 2). Tacrolimus and methotrexate were used for graft-versus-host disease (GVHD) prophylaxis. Forty-seven patients were included. All patients experienced complete remission, with only 2 relapses. With a median follow-up time of 60 months (range, 19-94), the estimated survival and progression-free survival rates were 85% and 83%, respectively. All 18 patients who were tested and had evidence of JH/bcl-2 fusion transcripts in the bone marrow at study entry experienced continuous molecular remission. The incidence of grade 2-IV acute GVHD was 11%. Only 5 patients were still undergoing immunosuppressive therapy at the time of last follow-up. We believe that the described results are a step forward toward developing a curative strategy for recurrent follicular lymphoma.

• Authors: Issa F Khouri, Peter McLaughlin, Rima M Saliba, Chitra Hosing, Martin Korbling, Ming S Lee, L Jeffrey Medeiros, Luis Fayad, Felipe Samaniego, Amin Alousi, Paolo Anderlini, Daniel Couriel, Marcos de Lima, Sergio Giralt, Sattva S Neelapu, Naoto T Ueno, Barry I Samuels, Fredrick Hagemeister, Larry W Kwak, Richard E Champlin
• Journal: Blood (Blood) Vol. 111 Issue 12 Pg. 5530-6 (Jun 15 2008) ISSN: 1528-0020 [Electronic] United States
• PMID: 18411419 (Publication Type: Clinical Trial, Phase II, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents
• Myeloablative Agonists
• Rituximab
• Cyclophosphamide
• Vidarabine
• fludarabine

Topics

• Adult
• Aged
• Antibodies, Monoclonal (administration & dosage, adverse effects)
• Antibodies, Monoclonal, Murine-Derived
• Antineoplastic Agents (administration & dosage, adverse effects)
• B-Lymphocytes (cytology)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage, adverse effects)
• Female
• Follow-Up Studies
• Graft vs Host Disease
• Graft vs Tumor Effect
• Hematopoietic Stem Cell Transplantation
• Humans
• Lymphoma, Follicular (drug therapy)
• Male
• Middle Aged
• Myeloablative Agonists (administration & dosage, adverse effects)
• Prospective Studies
• Recurrence
• Remission Induction
• Rituximab
• Survival Rate
• Transplantation Chimera
• Transplantation Conditioning (methods)
• Transplantation, Homologous
• Vidarabine (administration & dosage, adverse effects, analogs & derivatives)