Clinical characteristics of schizotypal-related obsessive-compulsive disorder.

Abstract

In this study we compared 15 patients with DSM-IV obsessive-compulsive disorder (OCD) and schizotypal personality disorder (SPD) and 31 non-SPD OCD patients. OCD-SPD patients had poorer insight, more negative symptoms, lower functioning, more antipsychotic augmentation and more first-degree relatives with schizophrenia-spectrum disorders. A distinct clinical phenotype of OCD associated with SPD should be considered when investigating etiopathogenetic mechanisms.

• Authors: Michael Poyurovsky, Sarit Faragian, Artashez Pashinian, Lilah Heidrach, Camil Fuchs, Ronit Weizman, Lorrin Koran
• Journal: Psychiatry research (Psychiatry Res) Vol. 159 Issue 1-2 Pg. 254-8 (May 30 2008) ISSN: 0165-1781 [Print] Ireland
• PMID: 18378321 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antipsychotic Agents

Topics

• Adult
• Age of Onset
• Antipsychotic Agents (therapeutic use)
• Comorbidity
• Diagnostic and Statistical Manual of Mental Disorders
• Family (psychology)
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• Israel (epidemiology)
• Logistic Models
• Male
• Mental Disorders (diagnosis, epidemiology)
• Obsessive-Compulsive Disorder (diagnosis, epidemiology, genetics)
• Phenotype
• Psychiatric Status Rating Scales (statistics & numerical data)
• Schizophrenia (diagnosis, epidemiology, genetics)
• Schizophrenic Psychology
• Schizotypal Personality Disorder (diagnosis, epidemiology, genetics)
• Severity of Illness Index