A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.

Abstract

Zinc deficiency represents a risk factor for carotid stenosis (CS) development. In mammals, members of the ZIP family regulate zinc uptake, and hZip2 is a human zinc importer upregulated by zinc depletion. The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls. CS patients showed an increased GG genotype frequency (60% vs. 47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by chi(2) test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.

• Authors: Robertina Giacconi, Elisa Muti, Marco Malavolta, Maurizio Cardelli, Sara Pierpaoli, Catia Cipriano, Laura Costarelli, Silvia Tesei, Vittorio Saba, Eugenio Mocchegiani
• Journal: Rejuvenation research (Rejuvenation Res) Vol. 11 Issue 2 Pg. 297-300 (Apr 2008) ISSN: 1549-1684 [Print] United States
• PMID: 18328005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amino Acids
• Cation Transport Proteins
• Codon
• SLC39A2 protein, human

Topics

• Aged
• Aging (genetics)
• Amino Acids (genetics)
• Carotid Artery Diseases (genetics)
• Case-Control Studies
• Cation Transport Proteins (genetics)
• Codon (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Humans
• Male
• Polymorphism, Genetic