Abstract | REASONS FOR PERFORMING STUDY: Absorption of endotoxin across ischaemic-injured mucosa is a major cause of mortality after colic surgery. Recent studies have shown that flunixin meglumine retards mucosal repair. Systemic lidocaine has been used to treat post operative ileus, but it also has novel anti-inflammatory effects that could improve mucosal recovery after ischaemic injury. HYPOTHESIS: METHODS: Horses were treated i.v. immediately before anaesthesia with either 0.9% saline 1 ml/50 kg bwt, flunixin meglumine 1 mg/kg bwt every 12 h or lidocaine 1.3 mg/kg bwt loading dose followed by 0.05 mg/kg bwt/min constant rate infusion, or both flunixin meglumine and lidocaine, with 6 horses allocated randomly to each group. Two sections of jejunum were subjected to 2 h of ischaemia by temporary occlusion of the local blood supply, via a midline celiotomy. Horses were monitored with a behavioural pain score and were subjected to euthanasia 18 h after reversal of ischaemia. Ischaemic-injured and control jejunum was mounted in Ussing chambers for measurement of transepithelial electrical resistance (TER) and permeability to lipopolysaccharide (LPS). RESULTS: CONCLUSIONS: Treatment with systemic lidocaine ameliorated the inhibitory effects of flunixin meglumine on recovery of the mucosal barrier from ischaemic injury, when the 2 treatments were combined. The mechanism of lidocaine in improving mucosal repair has not yet been elucidated.
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Authors | V L Cook, J Jones Shults, M McDowell, N B Campbell, J L Davis, A T Blikslager |
Journal | Equine veterinary journal
(Equine Vet J)
Vol. 40
Issue 4
Pg. 353-7
(Jun 2008)
ISSN: 0425-1644 [Print] United States |
PMID | 18321812
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Lipopolysaccharides
- flunixin meglumine
- Lidocaine
- Clonixin
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Topics |
- Anesthetics, Local
(blood, therapeutic use)
- Animals
- Clonixin
(analogs & derivatives, pharmacology)
- Electric Impedance
- Female
- Horse Diseases
(drug therapy, prevention & control)
- Horses
- Infusions, Intravenous
(veterinary)
- Intestinal Mucosa
(blood supply, drug effects)
- Ischemia
(drug therapy, prevention & control, veterinary)
- Jejunum
(blood supply, drug effects, metabolism)
- Lidocaine
(blood, therapeutic use)
- Lipopolysaccharides
(pharmacology)
- Male
- Pain Measurement
(veterinary)
- Permeability
(drug effects)
- Reperfusion
(veterinary)
- Time Factors
- Tissue Culture Techniques
(veterinary)
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