Abstract |
In this paper, we report two patients with mixed connective tissue disease ( MCTD) who developed aseptic meningitis. In both cases, the concentrations of IFN-gamma and IL-6 in cerebrospinal fluid (CSF) were increased. In the first case, with non-steroidal anti-inflammatory drugs ( NSAIDs)-induced meningitis, where anti-U1RNP antibodies (Abs) were not detected in CSF, NSAIDs induced both IFN-gamma and IL-6 secretion from peripheral blood mononuclear cells in vitro. In the second case, with disease-associated meningitis, anti-U1RNP Abs were detected also in CSF. Of note, anti-U1RNP Abs appeared to be more concentrated in CSF than in serum and CSF-anti-U1RNP Ab titer was correlated with disease activity. We suggest that IFN-gamma and IL-6 may be involved in both disease-associated and drug-induced aseptic meningitis, whereas CSF-anti-U1RNP Abs is detected only in a patient with MCTD-associated aseptic meningitis.
|
Authors | Yoshimasa Fujita, Takao Fujii, Ran Nakashima, Masao Tanaka, Tsuneyo Mimori |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 18
Issue 2
Pg. 184-8
( 2008)
ISSN: 1439-7595 [Print] England |
PMID | 18283524
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Autoantibodies
- Cytokines
- Interleukin-6
- Ribonucleoprotein, U1 Small Nuclear
- Interleukin-4
- Interferon-gamma
- Prednisolone
|
Topics |
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- Autoantibodies
(immunology)
- Cells, Cultured
- Cytokines
(cerebrospinal fluid)
- Female
- Humans
- Interferon-gamma
(cerebrospinal fluid)
- Interleukin-4
(cerebrospinal fluid)
- Interleukin-6
(cerebrospinal fluid)
- Leukocytes, Mononuclear
(drug effects, immunology)
- Lymphocyte Activation
(drug effects)
- Meningitis, Aseptic
(cerebrospinal fluid, diagnosis, immunology)
- Mixed Connective Tissue Disease
(cerebrospinal fluid, diagnosis, immunology)
- Prednisolone
(therapeutic use)
- Ribonucleoprotein, U1 Small Nuclear
(immunology)
- Treatment Outcome
|