Abstract | BACKGROUND: METHODS: Twenty-one STEMI patients who underwent successful primary PCI were evaluated. Contrast-enhanced CMR was performed within 7 days of presentation and repeated at three months. TIMI Flow Grade (TFG), corrected TIMI Frame Count ( cTFC), TMPG, MO, infarct size, and left ventricular ejection fraction (EF) were assessed. RESULTS: The median peak creatine phosphokinase (CPK) was 1,775 IU/l (interquartile range 838-3,321). TFG 3 was present following PCI in 19 (90%) patients. CMR evidence of MO was present in 52% following PCI. Abnormal post-PCI TMPG (0/1/2) was present in 48% of subjects and was associated with MO on CMR (90% MO with TMPG 0/1/2 vs. 18% MO with TMPG 3, P < 0.01). Abnormal post-PCI TMPG was also associated with a greater peak CK (median 3,623 IU/l vs. 838 IU/l, P < 0.001) and greater relative infarct size (17.3% vs. 5.2%, P < 0.01). CONCLUSION: Among STEMI patients undergoing primary PCI, post-PCI TMPG correlates with CMR measures of MO and infarct size. The combined use of both metrics in a comprehensive assessment of microvascular integrity and infarct size following STEMI may aid in the evaluation of future therapeutic strategies.
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Authors | Evan Appelbaum, Ajay J Kirtane, Alicia Clark, Yuri B Pride, Eli V Gelfand, Caitlin J Harrigan, Kraig V Kissinger, Warren J Manning, C Michael Gibson |
Journal | Journal of thrombosis and thrombolysis
(J Thromb Thrombolysis)
Vol. 27
Issue 2
Pg. 123-9
(Feb 2009)
ISSN: 1573-742X [Electronic] Netherlands |
PMID | 18246410
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
- Cardiovascular Diseases
(diagnosis)
- Coronary Angiography
(methods)
- Coronary Circulation
- Electrocardiography
- Female
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Microcirculation
- Middle Aged
- Myocardial Infarction
(complications, pathology, physiopathology, therapy)
- Stroke Volume
- Thrombolytic Therapy
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