[A morphological and histochemical study of the large intestine of white mice with experimental trichocephaliasis and after the action of some anthelmintic preparations].

Abstract

Administration of levamisole, oxphendasole in dose 10 mg/kg and especially of ivomeck in dose 0.01 ml/kg of body weight damages the large intestine mucosa of intact mice and of mice with experimental T. muris infection. Epithelial cells dystrophy, the goblet cells destruction and the diffuse leucocytes infiltration of the intestinal wall, maximal 12 hours after the drugs administration, were most marked in animals treated with ivomeck. Pathomorphological changes in the gut mucosa after the drug administration to infected animals were significantly higher than in intact ones. That permits to conclude that the damage of the intestinal wall is due to the toxicity of the drugs, and perhaps with the damage of mucosa by the nonspecific (allergic) response to the chemotherapy.

• Authors: N V Chebyshev, E F Kotovskiĭ, I A Berechikidze
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1991 Nov-Dec Issue 6 Pg. 36-9 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskoe i gistokhimicheskoe issledovanie tolstoĭ kishki belykh mysheĭ pri éksperimental'nom trikhotsefaleze i posle vozdeĭstviia nekotorykh antigel'mintnykh preparatov.
• PMID: 1818246 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anthelmintics
• Antinematodal Agents
• Benzimidazoles
• Levamisole
• Ivermectin
• oxfendazole

Topics

• Animals
• Anthelmintics (therapeutic use)
• Antinematodal Agents (therapeutic use)
• Benzimidazoles (therapeutic use)
• Drug Evaluation, Preclinical
• Female
• Histocytochemistry
• Intestine, Large (drug effects, metabolism, pathology)
• Ivermectin (therapeutic use)
• Levamisole (therapeutic use)
• Male
• Mice
• Time Factors
• Trichuriasis (drug therapy, metabolism, pathology)