Breast cyst fluid plasmin activity and its effect on TGF-beta2 activation.

Abstract

There are two types of breast cyst and women with apocrine breast cyst may have a higher risk of developing breast cancer than cyst lined by flattened epithelium. Transforming growth factor-beta's growth inhibitory effect on epithelial cells suggests a potential protective role in breast cancer. The aim of this study was to investigate the presence of plasmin in both breast cyst groups and the possible role of plasmin on transforming growth factor beta activation. Presence of high plasmin level may indicate its importance on activation process, but some other proteases may also involve in this activation mechanism.

• Authors: Hakan Erbas, Oya Erten, Mehmet E Irfanoglu
• Journal: Cancer investigation (Cancer Invest) Vol. 26 Issue 1 Pg. 22-7 (Feb 2008) ISSN: 1532-4192 [Electronic] England
• PMID: 18181041 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Transforming Growth Factor beta2
• alpha-2-Antiplasmin
• plasmin-plasmin inhibitor complex
• Fibrinolysin

Topics

• Breast Cyst (metabolism)
• Cyst Fluid (chemistry)
• Enzyme Activation (physiology)
• Enzyme-Linked Immunosorbent Assay
• Female
• Fibrinolysin (metabolism)
• Fibrocystic Breast Disease (metabolism)
• Humans
• Transforming Growth Factor beta2 (metabolism)
• alpha-2-Antiplasmin (metabolism)