Abstract | INTRODUCTION: MATERIALS AND METHODS: Anti- protein Z antibodies were measured by commercially available ELISA in 102 LA-patients (69 with and 33 without thrombosis) and 33 healthy volunteers. RESULTS: Elevated anti- protein Z IgG and/or IgM, IgG and IgM antibody levels were more prevalent among LA-patients (62%, 35%, 45%) than among controls (50%, 25%, 25%), but the difference was only statistically significant for the IgM subtype (p=0.037). Anti- protein Z IgG (odds ratio [OR] 0.77, 95% confidence interval [CI] 0.33-1.82) and IgM (OR 0.82, CI 0.35-1.88) antibody levels in the highest quartile of controls did not indicate an increased risk for thrombosis among LA-patients. Anti- protein Z IgG (OR 2.0, CI 0.5-7.6) and IgM (OR 1.8, CI 0.5-6.6) antibody levels in the highest quartile of controls were more prevalent in women with pregnancy loss than in those with normal pregnancy, but the difference was not statistically significant. CONCLUSION: Our data indicate that anti- protein Z antibodies are not associated with thrombosis in LA. However, women with LA and pregnancy loss show a tendency towards elevated anti- protein Z antibody levels.
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Authors | Thomas Sailer, Rainer Vormittag, Silvia Koder, Peter Quehenberger, Alexandra Kaider, Ingrid Pabinger |
Journal | Thrombosis research
(Thromb Res)
Vol. 122
Issue 2
Pg. 153-60
( 2008)
ISSN: 0049-3848 [Print] United States |
PMID | 18031797
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Proteins
- Lupus Coagulation Inhibitor
- plasma protein Z
- Factor Xa
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Topics |
- Abortion, Spontaneous
- Adult
- Aged
- Blood Proteins
(chemistry)
- Cohort Studies
- Factor Xa
(chemistry)
- Female
- Hemostasis
- Humans
- Lupus Coagulation Inhibitor
(metabolism)
- Male
- Middle Aged
- Pregnancy
- Pregnancy Complications
- Recurrence
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