[Effect of atorvastatin on carotid intima-medial of thickness of primary hypertension patients of Han nationality in China].

Abstract

OBJECTIVES:

To investigate the efficacy of 10 mg or 20 mg atorvastatin + long acting antihypertensive in carotid intima-medial thickness (IMT).

METHODS:

151 patients of Han nationality in South China with mild hypertensive were randomly divided into 3 groups: atorvastatin 10 mg group (n = 50) receive 10 mg atorvastatin and amlodipine + benazepril; atorvastatin 20 mg group (n = 61) receive 20 mg atorvastatin and amlodipine + benazepril; the control group (n = 40) receive amlodipine + benazepril. The patients were detected IMT, vascular function, lipids and inflammatory factor in pretherapy and every 3 months.

RESULTS:

atorvastatin 10 mg or 20 mg groups have significantly change contrast to control group: (1) IMT was decreased (P < 0.01). (2) Deltadia-P% and Deltadia-N% were increased (P < 0.01). (3) LDL-C level was decreased by 30% in a atorvastatin 10 mg group and 40.48% in 20 mg group respectively (P < 0.01).

CONCLUSION:

Atorvastatin delays the development of atherosclerosis in hypertensive patients, improves endothelial function, and strengthens the effect of lipid-lowering.

• Authors: Jing Wu, Gang Wu, Mei-ping Wang, Dong-lin Liu, Zhi-jian Hu, Guo-ying Xu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 87 Issue 31 Pg. 2215-7 (Aug 21 2007) ISSN: 0376-2491 [Print] China
• PMID: 18001533 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anticholesteremic Agents
• Antihypertensive Agents
• Benzazepines
• Cholesterol, LDL
• Heptanoic Acids
• Pyrroles
• Amlodipine
• Atorvastatin
• benazepril

Topics

• Aged
• Amlodipine (therapeutic use)
• Anticholesteremic Agents (therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Atorvastatin
• Benzazepines (therapeutic use)
• Carotid Arteries (drug effects, pathology)
• China
• Cholesterol, LDL (blood)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Endothelium, Vascular (drug effects, physiopathology)
• Female
• Heptanoic Acids (therapeutic use)
• Humans
• Hypertension (blood, drug therapy, physiopathology)
• Male
• Middle Aged
• Pyrroles (therapeutic use)
• Time Factors
• Treatment Outcome
• Tunica Intima (drug effects, pathology)
• Tunica Media (drug effects, pathology)