Abstract |
Conjugates of curcumin to two differently sized poly( ethylene glycol) molecules were synthesized in an attempt to overcome the low aqueous solubility of this natural product with cytotoxic activity against some human cancer cell lines. The soluble conjugates exhibited enhanced cytotoxicity as compared to that of the parent drug. Synthesis, analyses of the rate of drug release, and cytotoxicity studies are herein reported. The water-soluble conjugates may provide information useful for the development of injectable curcumin conjugates.
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Authors | Ahmad Safavy, Kevin P Raisch, Sushma Mantena, Leisa L Sanford, Simon W Sham, N Rama Krishna, James A Bonner |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 50
Issue 24
Pg. 6284-8
(Nov 29 2007)
ISSN: 0022-2623 [Print] United States |
PMID | 17973470
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antineoplastic Agents
- Water
- Polyethylene Glycols
- Curcumin
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Cell Line, Tumor
- Curcumin
(chemistry)
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Polyethylene Glycols
(chemistry)
- Solubility
- Structure-Activity Relationship
- Water
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