Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver.

Abstract

Plasma high density lipoprotein (HDL)-cholesterol levels are inversely correlated with the incidence of cardiovascular diseases. HDL is mainly assembled in the liver through the ATP-binding cassette transporter (ABCA1) pathway. In humans, plasma HDL-cholesterol levels are positively correlated with plasma adiponectin (APN) concentrations. Recently, we reported that APN enhanced apolipoprotein A-I (apoA-I) secretion and ABCA1 expression in HepG2 cells. In the present study, we investigated HDL assembly in APN-knockout (KO) mice. The apoA-I protein levels in plasma and liver were reduced in APN-KO mice compared with wild-type-mice. The ABCA1 expression in liver was also decreased in APN-KO mice. APN deficiency might cause the impaired HDL assembly by decreasing ABCA1 expression and apoA-I synthesis in the liver.

• Authors: Hiroyuki Oku, Fumihiko Matsuura, Masahiro Koseki, Jose C Sandoval, Miyako Yuasa-Kawase, Kazumi Tsubakio-Yamamoto, Daisaku Masuda, Norikazu Maeda, Tohru Ohama, Masato Ishigami, Makoto Nishida, Ken-ichi Hirano, Shinji Kihara, Masatsugu Hori, Iichiro Shimomura, Shizuya Yamashita
• Journal: FEBS letters (FEBS Lett) Vol. 581 Issue 26 Pg. 5029-33 (Oct 30 2007) ISSN: 0014-5793 [Print] England
• PMID: 17936760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABCA1 protein, human
• ATP Binding Cassette Transporter 1
• ATP-Binding Cassette Transporters
• Adiponectin
• Apolipoprotein A-I
• Lipoproteins, HDL
• Lipoproteins, VLDL

Topics

• ATP Binding Cassette Transporter 1
• ATP-Binding Cassette Transporters (genetics, metabolism)
• Adiponectin (genetics, physiology)
• Animals
• Apolipoprotein A-I (blood, metabolism)
• Lipoproteins, HDL (blood, metabolism)
• Lipoproteins, VLDL (blood)
• Liver (metabolism)
• Mice
• Mice, Knockout