[Prevention of in vivo formation of NMBz A and the formation of oesophageal tumour by tea in rats].

Abstract

Five groups of rats (22 per group) were intubated with precursors of N-Nitrosomethylbenzylamine (NMBzA), i.e. methylbenzylamine (1 mmol/kg) and sodium nitrite (0.5 mmol/kg), and five varieties of Chinese tea. One positive control group was intubated with precursors of NM2A without tea and one negative control group with tap water and sodium nitrite. After 12 week's treatment, significantly less lesions and papillomas in esophageal mucosa, examined by naked eye or by microscope, were found in the tea-treated groups than in the non-tea-treated positive control group. The results confirmed the anti-tumour ability of Chinese tea by blocking the in vivo formation of NMBzA in rats.

• Authors: Y Xu, C Han
• Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] (Zhonghua Yu Fang Yi Xue Za Zhi) Vol. 25 Issue 4 Pg. 201-4 (Jul 1991) ISSN: 0253-9624 [Print] China
• PMID: 1782821 (Publication Type: English Abstract, Journal Article)

Chemical References

• Benzylamines
• Carcinogens
• Plant Extracts
• Tea
• N-methylbenzylamine
• nitrosobenzylmethylamine
• Sodium Nitrite
• Dimethylnitrosamine

Topics

• Animals
• Benzylamines
• Carcinogens
• Dimethylnitrosamine (analogs & derivatives)
• Esophageal Neoplasms (chemically induced, prevention & control)
• Male
• Papilloma (chemically induced, prevention & control)
• Plant Extracts (pharmacology, therapeutic use)
• Rats
• Rats, Inbred Strains
• Sodium Nitrite
• Tea