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Myotonic response induced by inhibitors of cholesterol biosynthesis.

Abstract
Steroid inhibitors of cholesterogenesis containing nitrogen-substituted side chains induced electromyographic myotonia in rats. Cholesterol reduction or desmosterol accumulation, per se, did not cause myotonia, and cholestrol feeding prevented drug-induced myotonia. Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia.
AuthorsN Winer, D M Klachko, R D Baer, P L Langley, T W Burns
JournalScience (New York, N.Y.) (Science) Vol. 153 Issue 3733 Pg. 312-3 (Jul 15 1966) ISSN: 0036-8075 [Print] United States
PMID17780007 (Publication Type: Journal Article)

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