Abstract |
With the capacities of multiple differentiation, immunoregulatory activities and easy handling for isolation and culture expansion, human bone marrow mesenchymal stem cells (MSCs) have been utilized in clinical trials for the prevention and treatment of graft-versus-host disease in allogeneic bone marrow transplantation, repair of bone and cartilage defects and treatment of cardiac infarction and liver injury. However, increasingly experimental data indicate that a great deal of issues, such as intra-neutralization of calf serum proteins into cultured MSCs, survival of engrafted cells and subsequent cell differentiation tendency, should be in stringent consideration before clinical trials are designed. In this paper, these issues that should be raised and solved in clinical trials with MSCs were reviewed.
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Authors | Wei-Wei Zhang, Zi-Kuan Guo |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 15
Issue 4
Pg. 901-4
(Aug 2007)
ISSN: 1009-2137 [Print] China |
PMID | 17708830
(Publication Type: Journal Article, Review)
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Topics |
- Bone Marrow Transplantation
(adverse effects)
- Clinical Trials as Topic
- Graft vs Host Disease
(prevention & control)
- Humans
- Mesenchymal Stem Cell Transplantation
- Mesenchymal Stem Cells
(cytology, drug effects)
- Research Design
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