Treatment with an oral fluoropyrimidine, S-1, plus cisplatin in patients who failed postoperative gemcitabine treatment for pancreatic cancer: a pilot study.

Abstract

BACKGROUND:

This study set out to evaluate, in patients with gemcitabine-resistant pancreatic cancer, the response rate and toxicity of S-1 plus cisplatin (CDDP).

METHODS:

Seventeen patients with histologically diagnosed invasive ductal pancreatic cancer were enrolled in this study. All patients had growing recurrent pancreas cancer despite the administration of gemcitabine. Thirteen patients underwent pancreatectomy, and 2 underwent choledochojejunostomy and gastrojejunostomy without pancreatectomy. S-1 (80 mg/m(2) per day) was orally administered for 21 consecutive days, followed by a 14-day rest period. CDDP (40 mg/m(2)) in 500 ml saline was administered by intravenous drip on day 8. This schedule was repeated every 5 weeks until the occurrence of disease progression, unacceptable toxicities, or the patient's refusal to continue.

RESULTS:

Five (29.4%) patients achieved a partial response and 2 (11.8%) had stable disease. In 5 of 15 patients (33.3%) who had elevated serum carbohydrate antigen (CA)19-9 levels at the start of treatment the CA19-9 was reduced by more than 50%. The median survival time was 10 months (range, 20 months), with 63.7% and 31.9% of patients alive at 6 and 12 months, respectively. Major adverse reactions in the 15 patients included gastrointestinal toxicities of grade 1 or 2. Only one patient (5.9%) developed grade 3 leucopenia.

CONCLUSION:

S-1 with CDDP has a promising effect against gemcitabine-resistant pancreatic cancer, with easily manageable toxicities. Further investigation of this regimen is warranted in patients with pancreatic cancer, especially in comparison with gemcitabine.

• Authors: Akira Togawa, Hideyuki Yoshitomi, Hiroshi Ito, Fumio Kimura, Hiroaki Shimizu, Masayuki Ohtsuka, Hiroyuki Yoshidome, Atsushi Kato, Shigeaki Sawada, Masaru Miyazaki
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 12 Issue 4 Pg. 268-73 (Aug 2007) ISSN: 1341-9625 [Print] Japan
• PMID: 17701005 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drug Combinations
• Deoxycytidine
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin
• Gemcitabine

Topics

• Administration, Oral
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Cisplatin (administration & dosage, adverse effects, therapeutic use)
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Drug Combinations
• Drug Resistance, Neoplasm
• Female
• Humans
• Male
• Middle Aged
• Oxonic Acid (administration & dosage, adverse effects, therapeutic use)
• Pancreatic Neoplasms (drug therapy, surgery)
• Pilot Projects
• Survival Analysis
• Tegafur (administration & dosage, adverse effects, therapeutic use)
• Treatment Failure
• Treatment Outcome
• Gemcitabine