[A case of curatively resected AFP producing gastric cancer with massive lymph node metastasis effectively treated by neoadjuvant-chemotherapy of S-1 and CDDP].

Abstract

A 65-year-old man who had AFP producing gastric cancer with massive lymph-node metastasis was admitted to our institution. Because of bulky lymph-node metastasis, the tumor was considered unresectable. He was treated with neoadjuvant chemotherapy of S-1 and cisplatin (CDDP).S-1 (80 mg/m2/day) was administered for 21 consecutive days followed by 14 days rest as one course,and CDDP (60 mg/m2) was infused over 2 hours on day 8. After 1 course, radiographic examination showed remarkable improvement in the tumor size of the stomach, and computed tomography showed markedly reduced paraaortic lymph node metastasis. However, surgery was performed after 3 weeks,because of the adverse effect of diarrhea grade 3 after one course of the chemotherapy. This is a rare case in which neoadjuvant chemotherapy of S-1 and CDDP may well be an effective treatment for unresectable AFP producing gastric cancer with bulky lymph-node metastasis.

• Authors: Kenji Mimatsu, Atsushi Kawasaki, Takatsugu Oida, Osamu Aramaki, Youichi Kuboi, Hisao Kano, Michitaka Ogura, Sadao Amano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 34 Issue 8 Pg. 1279-82 (Aug 2007) ISSN: 0385-0684 [Print] Japan
• PMID: 17687213 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• alpha-Fetoproteins
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Adenocarcinoma (drug therapy, metabolism, secondary, surgery)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Drug Combinations
• Gastrectomy
• Humans
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Oxonic Acid (administration & dosage)
• Preoperative Care
• Stomach Neoplasms (drug therapy, metabolism, pathology, surgery)
• Tegafur (administration & dosage)
• alpha-Fetoproteins (biosynthesis)