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Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation.

Abstract
Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.
AuthorsT Takahashi, H Shimizu, H Morimatsu, K Inoue, R Akagi, K Morita, S Sassa
JournalMini reviews in medicinal chemistry (Mini Rev Med Chem) Vol. 7 Issue 7 Pg. 745-53 (Jul 2007) ISSN: 1389-5575 [Print] Netherlands
PMID17627585 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Heme
  • Heme Oxygenase-1
Topics
  • Acute Disease
  • Animals
  • Heme (metabolism)
  • Heme Oxygenase-1 (analysis, metabolism)
  • Humans
  • Inflammation (enzymology, prevention & control)
  • Oxidative Stress

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