Abstract |
Free heme contributes as a major threat to the oxidative tissue injuries because it catalyzes the formation of reactive oxygen species. When free heme concentration is increased, it results in the induction of heme oxygenase-1 (HO-1), which then breaks free heme down. As such, HO-1 plays a pivotal role in the protection of tissues from oxidative injuries.
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Authors | T Takahashi, H Shimizu, H Morimatsu, K Inoue, R Akagi, K Morita, S Sassa |
Journal | Mini reviews in medicinal chemistry
(Mini Rev Med Chem)
Vol. 7
Issue 7
Pg. 745-53
(Jul 2007)
ISSN: 1389-5575 [Print] Netherlands |
PMID | 17627585
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Acute Disease
- Animals
- Heme
(metabolism)
- Heme Oxygenase-1
(analysis, metabolism)
- Humans
- Inflammation
(enzymology, prevention & control)
- Oxidative Stress
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